免校准光镊技术特点


▣ 光阱测量模块

• 专利力谱测量技术——LIGHT MOMENTUM METHOD专利号:EP 2,442,316

• 直接测力,无需校准;

• 每个光阱单独测力;

• 可整合多种成像模式:如明场、EPI、TIRF、共聚焦以及超分辨;

• 力学分辨率:<50 fN

• 样品定位精度:1 nm


▣ 光阱生成模块

• 2D 快速光阱操控 (最高可达 25 kHz);

• 独立光阱亚纳米精度精确控制;

• 工作视野:80 μm x 80 μm(60X);

• 光阱刚度:1pN/mW·μm;

• 激光强度: >0.5 W


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左:光阱测量模块;右:光阱生成模块

■ SCIENCE:细胞核充当细胞形状变形的弹性机械转换器,并控制细胞的动态行为



■ Nature Physics:分裂过程中细胞内硬度降低和粘弹性流动性增加



■ Nature Physics:周期性障碍物调节膜张力传导,实现局部机械传递



■ 巨型单层囊泡(giant unilamellar vesicles, GUVs)研究



■ T细胞与肿瘤细胞相互作用




• Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity. Nature Communications (2025): https://doi.org/10.1038/s41467-025-56894-8

• Periodic Obstacles Regulate Membrane Tension Propagation to Enable Localized Mechanotransduction. Biorxiv (2025):https://doi.org/10.1101/2025.01.14.632796

• Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology. Nature Nanotechnology (2025): DOI: 10.1038/s41565-024-01830-y

• Accessing activity and viscoelastic properties of artificial and living systems from passive measurement. Nature Materials (2024): https://doi.org/10.1038/s41563-024-01957-2

• A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing. Nature Cell Biology (2023): https://doi.org/10.1038/s41556-023-01247-0

• The laminin-keratin link shields the nucleus from mechanical deformation and signaling. Nature Materials (2023):  https://doi.org/10.1101/2022.03.01.482474

• Intracellular softening and increased viscoelastic fluidity during division. Nature Physics (2021). https://doi.org/10.1038/s41567-021-01368-z

• An asymmetric mechanical code ciphers curvature-dependent proprioceptor activity. SCIENCE ADVANCES (2021) DOI: 10.1126/sciadv.abg4617

• The force loading rate drives cell mechanosensing through both reinforcement and fluidization. Nature Communications (2021).  https://doi.org/10.1038/s41467-021-24383-3

• The nucleus measures shape changes for cellular proprioception to control dynamic cell behaviour. SCIENCE (2020) DOI: 10.1126/science.aba2644


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